By 1810, the total population of Jefferson county was 11,694. The number of slaves was 3,488.
100 Men from Jefferson County enlisted in the military in Charles Town in order to fight in the War of 1812. Men from Jefferson County seved in the 55th Regiment of the war.
A notable flood at Harper's Ferry causes considerable damage to property due to a rainy spring.

The Shenandale Springs resort opens to the public, beginning with about ten wooden cottages. In 1821, a two story hotel was added to the property. The large spring on the property was reported to have a mild laxative quality, while the other mineral springs featured a slight odor of sulphur.
A detailed history on the resort by William Theriault is located online here.
The first "West" Virginia library of record was opened in Harpers Ferry by the Harpers Ferry Library Society.
An epidemic of malignant disease stalked travelers and residents of eastern Jefferson County. The outbreak caused many fatalities in Shepherdstown and Harpers Ferry. This "unknown" disease may have been a form of Typhus Fever.
The first newspaper marketed to women was published by John S. Gallaher in Harpers Ferry and titled the Ladies Garland. The paper was published from February 14, 1824 to June 7, 1828 every Saturday evening at the Harpers Ferry Free Press, and was one of the very first papers targeted specifically to women in the United States.
View libraries which possess issues of this paper or find out more about the life of John Gallaher.
The armory was entirely consumed by fire, causing $100,000 worth of damage to buildings, materials, and equipment. The fire also caused the loss of wages of 200 laborers, estimated between 10 and 20,000.
"Mudfort" was officially established as the town of Bolivar, named after Simon Bolivar.

Throughout the 1830's and 40's Jefferson County focused on the expansion of infastructure, and saw the creation of a multitude of new roads, railroads, bridges, and other items of transportational value.
After being fired from his position at the armory, Ebenezer Cox shot and killed Superintendent Colonel Thomas B. Dunn. Although Cox implicated numerous other individuals in the plot of Col. Dunn's pre-meditated murder, only Cox was found guilty of the crime. Cox was later sentenced to death.
A cholera epidemic that is quickly taking over the nation hits Jefferson County hard. Cholera, often coined Blue Death, infects the small intestine and causes severe dehydration (often causing the sick to turn blue). The infection was common in slaves quarters and canal workers.
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